Wildfires are a worldwide disturbance with unclear implications for stream water quality. We examined stream water chemistry responses immediately (<1 month) following a wildfire by measuring over 40 constituents in four gauged coastal watersheds that burned at low to moderate severity. Three of the four watersheds also had pre-fire concentration-discharge data for 14 constituents: suspended sediment (SSfine), dissolved organic and inorganic carbon (DOC, DIC), specific UV absorbance (SUVA), major ions (Ca2+, K+, Mg2+, Na+, Cl−, SO42-, NO3-, F-), and select trace elements (total dissolved Mn, Fe). In all watersheds, post-fire stream water concentrations of SSfine, DOC, Ca2+, Cl−, and NO3- changed when compared to pre-fire data. Post-fire changes in SO42-, K+, Na+, Mg2+, DIC, SUVA, and total dissolved Fe were also found for at least two of the three streams. For constituents with detectable responses to wildfire, post-fire changes in the slopes of concentration-discharge relationships commonly resulted in stronger enrichment trends or weaker dilution trends, suggesting that new contributing sources were surficial or near the surface. However, a few geogenic solutes, Ca2+, Mg2+, and DIC, displayed stronger dilution trends at nearly all sites post-fire. Moreover, fire-induced constituent concentration changes were highly discharge and site-dependent. These similarities and differences in across-site stream water chemistry responses to wildfire emphasize the need for a deeper understanding of landscape-scale changes to solute sources and pathways. Our findings also highlight the importance of being explicit about reference points for both stream discharge and pre-fire stream water chemistry in post-fire assessment of concentration changes.