Peatlands store one-third of the total global soil carbon (C.) despite covering only 3-4% of the global land surface. Most peatlands are distributed in mid-high latitude regions and are even in permafrost regions, are sensitive to climate change and are disturbed by wildfire. Although several studies have focused on the impact of historical climate change and regional human activities on the C. accumulation process in these peatlands, the impact of these factors on the stability of the C. pool remains poorly understood. Here, based on the 210Pb age-depth model, we investigated the historical variations of C. stability during the last 150 years for five typical peatlands in the northern Great Khingan Mountains (Northeast China), an area located in a permafrost region that is sensitive to climate change and to wildfires, which have clearly increased due to regional human activities. The results showed that low C. accumulation rates (CARs) and weakly C. stability in studied peatlands before 1900. While, the increasing anthropogenic wildfire frequency and the residual products (e.g. pyrogenic carbon) increased the CARs and C. stability in peatlands from 1900 to 1980. The mean July temperature is the most important climate factor for peatlands C. stability. After 1980, due to the low wildfire frequencies influenced by human policies, increasing temperatures and decreasing precipitation not only increased the CARs but also markedly increased the C. stability of the peatlands C. pool in the northern Great Khingan Mountains, especially after 2000.