Most regions of the United States are projected to experience a higher frequency of severe droughts and longer dry periods as a result of a warming climate. Even if current drought regimes remain unchanged, higher temperatures will interact with drought to exacerbate moisture limitation and water stress. Observations of regional-scale drought impacts and expectations of more frequent and severe droughts prompted a recent state-of-science synthesis (Vose et al. 2016). The current volume builds on that synthesis and provides region-specific management options for increasing resilience to drought for Alaska and Pacific Northwest, California, Hawai‘i and U.S.-Affiliated Pacific Islands, Interior West, Great Plains, Northeast and Midwest, and Southeast.