Increased wildfire activity (e.g. number of starts, area burned, fire behaviour) across the western United States in recent decades has heightened interest in resolving climate-fire relationships. Macroscale climate-fire relationships were examined in forested and non-forested lands for eight Geographic Area Coordination Centers in the western United States, using area burned derived from the Monitoring Trends in Burn Severity dataset (1984-2010). Fire-specific biophysical variables including fire danger and water balance metrics were considered in addition to standard climate variables of monthly temperature, precipitation and drought indices to explicitly determine their optimal capacity to explain interannual variability in area burned. Biophysical variables tied to the depletion of fuel and soil moisture and prolonged periods of elevated fire-danger had stronger correlations to area burned than standard variables antecedent to or during the fire season, particularly in forested systems. Antecedent climate-fire relationships exhibited inter-region commonality with area burned in forested lands correlated with winter snow water equivalent and emergent drought in late spring. Area burned in non-forested lands correlated with moisture availability in the growing season preceding the fire year. Despite differences in the role of antecedent climate in preconditioning fuels, synchronous regional fire activity in forested and non-forested lands suggests that atmospheric conditions during the fire season unify fire activity and can compound or supersede antecedent climatic stressors. Collectively, climate-fire relationships viewed through the lens of biophysical variables provide a more direct link to fuel flammability and wildfire activity than standard climate variables, thereby narrowing the gap in incorporating top-down climatic factors between empirical and process-based fire models.